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Program Overview

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Program Overview

Symposia
42
Animal physiology in extreme environments
Chair: John Speakman , Chinese Academy of Sciences & University of Aberdeen

Co-Chair: Monica Trondrud , Norwegian University of Life Sciences
John Speakman, Chinese Academy of Sciences & University of Aberdeen

Measuring energy expenditure in the field: insights from extraordinary animals

Clare Stawski, Norwegian University of Technology and Science

Physiological and behavioural plasticity of small mammals in a changing environment

Andreas Fahlman, Fundacin oceanografic de la Comunitat valenciana, Spain/ Global Diving Research, Canada

Avoiding the bends: a new hypothesis that explains how stress may cause mass stranding of cetaceans

Alina Evans, Inland Norway University of Applied Sciences

Hypometabolism in large Arctic mammals

Liv Monica Trondrud, Norwegian University of Life Sciences

Life on a tight budget - Svalbard reindeers adaption to extreme seasonality
Astrocyte: a central regulator of synapse connectivity
Chair: Schuichi Koizumi , University of Yamanashi

Co-Chair: Baljit Khakh , UCLA
Sponsored by the Physiological Society of Japan
Schuichi Koizumi, Dept Neuropharmacol, Grad Sch Med, University of Yamanasi, GLIA center, Univ Yamanashi, JAPAN

Control of cortical network by astrocytes via a single molecule mGluR5

Baljit Khakh, Physiology and Neurobiology David Geffen School of Medicine, UCLA, USA

Astrocytic control of neuronal circuits and behaviors

Won-Suk Chung, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), South Korea

Hippocampal synapse plasticity controlled by astrocytic phagocytosis

Misa Arizono, Interdisciplinary Institute for Neuroscience, Universit de Bordeaux, France

Dissecting astrocyte physiology with live super-resolution microscopy

Tetsuya Takano, Department of Neurophysiology Keio University School of Medicine, Tokyo, Japan

Tripartite synaptic cleft proteome discoveries astrocyte-mediated inhibition in vivo
Central nervous mechanisms that control circulation and breathing to maintain brain metabolic homeostasis
Chair: Sheng Wang , Hebei Medical University

Co-Chair: Anja G Teschemacher , University of Bristol
Patrick Hosford, RIKEN

Vagal tone, brain perfusion and cognitive function in later life

Anja Teschemacher, University of Bristol

How glia talks to neurones

Sheng Wang, Hebei Medical University

Circuit-and cell type-specific regulation of breathing in the NTS

Shahriar Sheikhbahaei, National Institute of Neurological Disorders and Stroke (NINDS)

Role of glia in control of respiratory networks

Fang Yuan, Hebei Medical University

Control of breathing by leptin singling in brainstem
Cytoskeleton t-tubules and membrane microdomains interplay in cardiac electro-mechanical coupling
Chair: Andrea Barbuti , University of Milan, Italy
Andrea Barbuti, University of Milan

Caveolae/caveolins' role in ion channel physiology and in the onset of cardiac arrhythmias

Hua-Qian Yang, Suzhou University

Beta-adrenergic signaling nanodomains in cardiac E-C coupling regulation

Michael Regnier, University of Washington, Seattle

Novel therapeutic strategies for dystrophin-associated cardiomyopathies

Ewa Rog-Zielinska,

Nano-scale deformation of cardiac t-tubules during stretch and contraction - structure and functional consequences.
Emerging roles of mitochondria and metabolism in the heart
Chair: Wang Wang , University of Washington

Co-Chair: Ming Zheng , Peking University Health Science Center
Heping Cheng, Peking University

TBD

Rong Tian, University of Washington

mitochondrial ATP and redox in heart disease development

Shey-Shing Sheu, Thomas Jefferson University

SR-mitochondria communication in adult cardiomyocytes: A close relationship where the Ca2+ has a lot to say

Sergio Lavandero, Universidad of Chile

TBD

Elizabeth Murphy, National Institutes of Health, United States

Regulation of mitochondrial PTP in heart disease
Endothelial signaling and cardiovascular repair
Chair: John Y-J Shyy , University of California, San Diego

Co-Chair: Ingrid Fleming , Institute for Vascular Signalling, Germany
Lei Shi, Dalian Medical University

The role of Septins in vessel remodeling (EC and SMC)

Ingrid Fleming, Goethe University Frankfurt

The role of calpains in communication between platelets and the vascular wall.

John Y-J Shyy, University of California, San Diego

The AMPK-ACE2 axis in vascular injury and repair

Chen Chen, Huazhong University of Science and Technology

The effects of virus-encoded miRNA on vascular homeostasis in dilated cardiomyopathy
Exercise and tryptophan metabolism: building more than just muscles
Chair: Thomas James Hawke , McMaster University
Jorge Ruas, Karolinska Institutet

Exercise-induced kynurenine pathway modulations and their effects on energy homeostasis

Jennifer Heisz, McMaster University

Alterations in kynurenine signaling in exercising older adults

Harry Gosker, Maastricht University

Kynurenine Metabolism in Patients with Chronic Obstructive Pulmonary Disease

Phillip Zimmer, Technische Universitt Dortmund

Exercise-induced immune- and neuromodulation in humans with and without disease

Edwin Lim, Macquarie University Centre for Motor Neuron Disease Research

Dysregulation of kynurenine metabolism in schizophrenia and multiple sclerosis
Exocytosis and fusion pore
Chair: Robert Zorec , Univerza v Ljubljani, Medicinska fakulteta

Co-Chair: Ling-Gang WU , National Institute of Health, USA
Ling-Gang WU, National Institute of Health

Super-resolution imaging of the fusion pore dynamics in chromaffin cells

Zhuan Zhou, Peking University, Beijing

Regulating quantal size through a GPCR-voltage sensor in chromaffin cells

Ira Milošević, Oxford University

Negative regulation of exocytosis by amisyn/STXBP6

Robert Zorec, Univerza v Ljubljani, Medicinska fakulteta

Fusion pore constriction in pituitary and gliocrine cells
Exotic models for cardiac translational research
Chair: Fabien Brette , INSERM

Co-Chair: Holly Shiels , University of Manchester
Fabien Brette, INSERM

Cardiac arrhythmia: beyond mice and rats

Ye Chen Izu, UC Davis

New trends in cardiac physiopathology from unconventional mammals model.

Holly Shiels, University of manchester

Fishing for insights in translational cardiac physiology
From structural to cellular bias of GPCR signaling in physiology
Chair: Yang Xiang , UCDavis
Chris Tate, Cambridge University

Molecular Basis for High-affinity Agonist Binding at the Beta1-adrenoceptor

Mark von zastrow, University of California, San Francisco, United States

GPCR signaling bias through sub cellular location.

Crystal Ripplinger, University of California at Davis, United States

Apex and base-dependent GPCR Signaling in cardiac tissues

Yulong Li, Peking University

Visualization of GPCR actions in animals

Laura Wingler, Duke University

Molecular Mechanisms of Biased Signaling at the Angiotensin Receptor
Functional regulation of subcortical peptidergic systems by sex-steroids
Chair: Vito Salvador Hernndez , Department of Physiology, School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.

Co-Chair: Andre de Sousa Mecawi , Laboratory of Neuroendocrinology Departamento de Biofsica - Escola Paulista de Medicina Universidade Federal de So Paulo
Dora Zelena, Institute of Experimental Medicine, Budapest; Centre for Neuroscience, Szentgothai Research Centre, Institute of Physiology, Medical School, University of Pcs, Pcs, Hungary

Sex-dependent vasopressinerg influence on stress adaptation and stress-related psychopathologies

Aimin Bao, Department of Mental Health, First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang Province Key Laboratory of Mental Disorder's Management, Hangzhou, China

Sexually dimorphic alterations in hypothalamic peptides in mood disorders.

Andre de Sousa Mecawi, Laboratory of Neuroendocrinology, Department of Biophysics, Escola Paulista de Medicina, Federal University of So Paulo, So Paulo, Brazil.

Estrogen receptor beta controls gene expression in the hypothalamic-neurohypophysial system.

Carla Daniela Cisternas, Instituto de Investigacin Mdica Mercedes y Martn Ferreyra, INIMEC-CONICET-Universidad Nacional de Crdoba, Crdoba, Argentina.

Epigenetic mechanisms at the interface between sex steroids and sex chromosome genes in the sexual differentiation of the hypothalamus.

Vito Salvador Hernandez, Department of Physiology, School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.

Density of GABAergic neurons in hypothalamic and limbic regions is modulated by testosterone levels
Gastrointestinal Immunophysiology and Gut Microbes
Chair: Linda Chia-Hui Yu , Graduate Insitute of Physiology, National Taiwan University College of Medicine

Co-Chair: Melanie Gareau , School of Veterinary Medicine, University of California, Davis, USA
Sponsored by the Chinese Physiological Society in Taipei, China
Melanie Gareau, School of Veterinary Medicine, University of California, Davis, USA

Development of the microbiota-gut-brain axis

Xiangsheng Fu, The affiliated Hospital of North Sichuan Medical College, Nanchang, China

Fusobacterium and colorectal cancer

Linda Chia-Hui Yu, Graduate Institue of Physiology, National Taiwan University College of Medicine

Microbiota dysbiosis and innate immunity in colorectal cancer

Colin Reardon, School of Veterinary Medicine, University of California, Davis, USA

Neuronal regulation of mucosal immune function
Genetic and metabolic control of aging
Chair: Baohua Liu , School of Basic Medical Sciences, Shenzhen University, China
Laura Niedernhofer, Institute on the Biology of Aging and Metabolism (iBAM); Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota

Therapeutically targeting senescent cells to treat age-related diseases

Evandro Fei FANG, Department of Clinical Molecular Biology, University of Oslo (UiO) Akershus University Hospital

Ageing drives NAD+ depletion and compromised mitophagy that guide AI-based drug screening to promote healthy longevity

Heng Ma, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fourth Military Medical University, Xi'an, China

Subclinical myocardial aging: Physiological and Translational Perspective on Aging-related cardiovascular disease

Moshi Song, Institute of Zoology, Chinese Academy of Sciences

Mitochondrial regulation of cardiac aging

Alex Chia Yu Chang, Department of Cardiology and Shanghai Institute of Precision Medicine, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine

Modeling aging and cardiovascular disease
High altitude: adaptation, acclimatisation and genetics
Chair: Max Gassmann , University of Zurich

Co-Chair: Martina Muckenthaler , University of Heidelberg
Max Gassmann, University of Zurich

Hemoglobin levels mirror the topography of Switzerland: Evidence for an ancient but precise oxygen sensing process

Martina Muckenthaler, University of Heidelberg

Iron at high altitude and anemia

Ainash Childebayeva, Max Planck Institute for the Science of Human History

Epigenetics and high-altitude adaptation
Marvels of calcium: coming in waves
Chair: Alicia Mattiazzi , Cardiovascular Research Center, Faculty of Medicine, National University of La Plata and National Research Council, Argentina

Co-Chair: Fatima M Leite , Department of Physiology and Biophysics, Universidade Federal de Minas Gerais (UFMG), MG, Belo Horizonte, Brazil
David A Esiner, University of Manchester

Calcium waves in the heart: from flux balance to arrhythmias

Karin R Sipido, Department of Cardiovascular Sciences, KU Leuven, The University of Leuven, Belgium

From myocyte calcium waves to arrhythmias after myocardial infarction

Fatima M Leite, Department of Physiology and Biophysics, Universidade Federal de Minas Gerais (UFMG), MG, Belo Horizonte, Brazil

Calcium in the liver: a taste for all seasons

Luis A Gonano, Cardiovascular Research Center, Faculty of Medicine, National University of La Plata and National Research Council, Argentina

RyR2 modulation and its consequences for systolic and dyastolic calcium release

Ivana Y Kuo, Department of Cell and Molecular Physiology, Loyola University Chicago, USA

Polycystin TRP channels are renal calcium signaling hubs
Microbiota, a challenge for systems physiology
Chair: Ken O'Halloran , Department of Physiology, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland.

Co-Chair: Sven Petterson , Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. Singapore Center for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore, Singapore)
Ken O'Halloran, Department of Physiology, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland.

microbiota-gut-brain axis signalling in cardiorespiratory control

Sven Pettersson, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. Singapore Center for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore, Singapore

Microbiota and skeletal muscle mass and function

Vienna Brunt, Integrative Physiology of Ageing Lab, University of Colorado Boulder, USA

Role of the gut microbiome in vascular ageing

Yuuki Obata, UT Southwestern Medical Center

TBD
Molecular and cellular aspects of cardiovascular disease
Chair: Grant N Pierce , University of Manitoba

Co-Chair: Balwant S Tuana , University of Ottawa
Connie W. Woo, Department of Pharmacology and Pharmacy, University of Hong Kong

Toll-like receptor signaling and cardiovascular disease: roles beyond innate immunity

Balwant S Tuana, University of Ottawa

Modeling cardiac disease for better translation

Grant Pierce, University of Manitoba

Modulation of cardiovascular disease by diet

Patrick Burgon, Qatar University

New targets in cardiac hypertrophy and heart failure

Kate Weeks, Baker Heart and Diabetes Institute

Molecular mechanisms underlying cardiac remodeling and dysfunction
Molecular mechanisms of cardiac Ca2+ signaling
Chair: Long-Sheng Song , University of Iowa

Co-Chair: Carlos Valverde , Uiversidad Nacional de La Plata
Shi-Qiang Wang, Peking Univ.

Transcriptional regulation of Ca2+ signaling in cardiomyocytes of hibernating mammal

Carlos Valverde, Uiversidad Nacional de La Plata

Ca2+ triggered arrhythmias, a seesaw game between SR Ca2+ release and uptake?

Ana Gomez, INSERM & Universit Paris Sud

Novel molecular mechanism of RyR2 mutation associated CPVT

Long-Sheng Song, University of Iowa

Junctophilin-2 in cardiac Ca2+ signaling and transcriptional regulation
Molecular physiology of chloride channels: how structure determines function in health and disease
Chair: Mayuree Rodrat , University of Bristol and Mahidol University

Co-Chair: Han-I Yeh , National Yang Ming Chiao Tung University
Thomas Jentsch, Max-Delbrck-Centrum fr Molekulare Medizin

Structure and function of the volume-regulated anion channel LRRC8

Raimund Dutzler, University of Zurich

Structure and function of the calcium-activated chloride channel TMEM16A

Henry Chien, Stanford University

Gating cycles of CLC proteins

Han-I Yeh, National Yang Ming Chiao Tung University

Molecular physiology of CFTR gating

Mayuree Rodrat, University of Bristol and Mahidol University

Upregulation of TRPV4-mediated urothelial sensory transduction underlies bladder overactivity in a murine model of IC/BPS
Multidimensional molecular control of neuroendocrine function
Chair: Denise D Belsham , University of Toronto

Co-Chair: Bredford Kerr , Universidad San Sebastin, Chile
Deborah M Kurrasch, University of Calgary

Molecular targets of environmental chemicals on the development of the hypothalamus.

Bredford Kerr, Universidad San Sebastin

Epigenetic regulation of energy homeostasis and its connection to healthy offspring.

Victor M Navarro, Harvard University

Role of hypothalamic neuropeptides on the onset of puberty.

Denise D Belsham, University of Toronto

Over-nutrition alters the microRNA and transcriptional profiles in hypothalamic neurons thereby altering expression of feeding-related neuropeptides.
Multiple organ dysfunction induced by SARS-Cov-2: an update on mechanisms of physiology and pathophysiology
Chair: Patricia R M Rocco , Federal University of Rio de Janeiro
Patricia R Rocco, Federal University of Rio de Janeiro

Different phenotypes of lung damage in Covid-19

Paolo Pelosi, University of Genoa

Coagulation disorders in Covid-19: Physiology and pathophysiology

Celso Caruso-Neves, Federal University of Rio de Janeiro

Kidney damage induced by SAR-COV-2: Potential role of the renin-angiotensin system

Fernanda Ferreira Cruz, Federal University of Rio de Janeiro

How does SARS-COV-2 affect the heart
Neuronal control of metabolism and immune function
Chair: Sabrina Diano , Institute of Human Nutrition, Columbia University Irving Medical Center

Co-Chair: Asaya Rolls , Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel
Diego Bohorquez, Department of Medicine, Duke University, Durham, NC, USA

Communication between intestinal sensory cells and gut neurons to carry messages about nutrients to the brain

Asaya Rolls, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel

Neuronal Control of Immune Function

Sabrina Diano, Institute of Human Nutrition, Columbia University Irving Medical Center

Neuronal sensing and control of nutrient metabolism

Hai Qi, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.

Nervous crosstalk to make antibodies
New mechanisms of neurogenic hypertension and therapeutic targets
Chair: De-Pei Li , University of Missouri

Co-Chair: Hui-Lin Pan , University of Texas MD Anderson Cancer Center
Hui-Lin Pan, University of Texas MD Anderson Cancer Center

α2δ-1 regulates synaptic NMDA receptors and sympathetic outflow in hypertension

Lisete Michelini, University of Sao Paulo

Transcytosis within preautonomic capillaries – a single mechanism determining both hypertension-induced blood-brain barrier dysfunction and exercise-induced correction

De-Pei Li, University of Missouri

Hypothalamic orexin signaling contributes to obesity-related hypertension

David Paterson, University of Oxford

Site-specific gene targeting to restore cardiac sympatho-vagal balance during hypertension
Novel functioning mechanisms of ion channels: heteromeric assembly, selective permeation and block
Chair: Yoshihiro Kubo , National Institute for Physiological Sciences, Department of Molecular & Cellular Physiology

Co-Chair: Eitan Reuveny , Department of Biomolecular Sciences, Weizmann Institute of Sciences
Guillaume Sandoz, Universit Cote d'Azur, CNRS, INSERM, iBV, Nice, France; Laboratories of Excellence, Ion Channel Science and Therapeutics, Nice, France

KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies

Yoshihiro Kubo, National Institute for Physiological Sciences, Department of Molecular & Cellular Physiology

A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K+ channel

Eitan Reuveny, Department of Biomolecular Sciences, Weizmann Institute of Sciences

Toxins mechanisms as a tool to study ion channel functions

Wenlei Ye, University of California, San Francisco, Department of Physiology

A tale of ‘Yin/Yang’: Dynamic Change of Ion Selectivity in TMEM16F
Novel therapeutics to target respiratory compromise in neuromuscular and neurodegenerative disease
Chair: David P Burns , University College Cork

Co-Chair: Mai K ElMallah , Dke University
Andrea Aliverti, Polytechnic University of Milan

Respiratory muscle action and rib-cage mechanics in childhood and adult neuromuscular disorders.

Mai K ElMallah, Duke University

Gene therapy for respiratory insufficiency in neuromuscular disorders

Gordon S Mitchell, University of Florida

Therapeutic acute intermittent hypoxia to restore breathing (and non-respiratory function) with spinal injury and ALS

Ana C Takakura, University of Sao Paulo

Therapeutic strategies for the prevention of respiratory abnormalities in pre-clinical models of Parkinson’s disease.

David P Burns, University College Cork

Accessory muscle support of breathing in dystrophin-deficient (mdx) mice.
Phosphatidylserine in cell signaling and cell function
Chair: Shmuel Muallem , NIH/NIDCR
Alenka Čopič, CNRS & Universit de Montpellier

PtdSer and membrane trafficking

Isabel Hernandez, Institute for Research in Biomedicine (IRB Barcelona)

PtdSer in MAMs and liver disease

Min Goo Lee, Yonsei University

Flippases, PtdSer and SARS-CoV-2 infection

Shmuel Muallem, NIH/NIDCR

PtdSer in the regulation of ion transporters
Prevention of the developmental programming of altered offspring physiology
Chair: Amanda Sferruzzi-Perri , University of Cambridge

Co-Chair: Luis Sobrevia , Pontificia Universidad Catlica de Chile, Chile
Mark Hanson, University of Southampton

Maternal factors and offspring and intergenerational health

Anthony Perkins, Griffith University

Selenium, placental mitochondria and pregnancy and offspring outcomes.

Mary Patti, Harvard University

Maternal diet, exercise intervention and offspring cardio-metabolic disease risk.

Jorge Lopez-Tello, University of Cambridge

Therapeutic potential of Bifidobacterium in improving fetal metabolic outcomes.

Tamara Saez, University of Alberta

Maternal obesity programming of vascular dysfunction.
Reactive oxygen species as mediators of neuromuscular aging: establishment of the novel ‘two hit’ hypothesis for sarcopenia.
Chair: Anne McArdle , University of Liverpool
Susan V Brooks, University of Michigan

Contribution of Both Pre- and Post-Synaptic Changes in the Initiation and Progression of Sarcopenia

Malcolm J Jackson, University of Liverpool

Mechanistic models to guide investigations into musculoskeletal ageing

Holly Van Remmen, Oklahoma Medical Research Foundation

Interventions to prevent or delay motor neuron loss and NMJ disruption: effects on muscle atrophy and weakness

Caroline A Staunton, University of Liverpool

Transcriptomic analysis of skeletal muscle ageing and nerve crush: defining the role of denervation in sarcopenia.

Bumsoo Ahn, Oklahoma Medical Research Foundation

Targeting mitochondrial hydrogen peroxide to mitigate sarcopenia
Recent advances in synapse physiology - International early-career symposium by the Young Physiologists (DPG)
Chair: Andreas Ritzau-Jost , Carl-Ludwig-Institute for Physiology, Faculty of Medicine, Leipzig University

Co-Chair: Gustavo Chaves , Klinikum Nrnberg
Changliang Liu, Department for Neurobiology, Harvard Medical School, MA, USA

Terminal control of dopamine signaling

Noa Lipstein, Leibniz-Forschungsinstitut fr Molekulare Pharmakologie (FMP) & and NeuroCure Excellence Cluster Dept. of Molecular Physiology and Cell Biology

Physiology and pathology of synaptic vesicle release

Jiesi Feng, IDG/McGovern Institute for Brain Research/School of Life Sciences, Peking University, China

Improved norepinephrine sensors shine lights on in vivo noradrenergic activities

Shuwen Chang, Brain Cognition and Brain Disease Institute, ShenZhen Institutes of Advanced Technology Chinese Academy of Sciences, China

Catching synaptic vesicle dynamics: Time-resolved electron microscopy and functional correlation

Andreas Ritzau-Jost, Carl-Ludwig-Institute for Physiology, Faculty of Medicine, Leipzig University

Novel insights from direct small nerve terminal recordings
Regulation of ion channels by lipids and lipid analogues
Chair: Takafumi Kawai , Osaka university

Co-Chair: Jianmin Cui , Washington university in st. louis
Sponsored by the Physiological Society of Japan
Fredrik Elinder, Linkping University

Lipophilic compounds from tree resin open voltage-gated potassium channels

Jianmin Cui, Washington university in st. louis

PIP2 is a necessary cofactor for IKs channel gating

Huaizong Shen, Westlake University

Structural basis for the modulation of human KCNQ4 by retigabine and linopirdine

Anna Duncan , University of Oxford

Lipid interactions of crowded membrane proteins revealed by molecular simulations: ion channels and related membrane proteins

Takafumi Kawai, Osaka University

Regulation of ion channels by voltage-sensing phosphatase in sperm flagellum
Renal calcium homeostasis revisited
Chair: Henrik Dimke , Part of Epithelial Transport Section (ETS) University of Southern Denmark
Henrik Dimke, Department of Cardiovascular and Renal Research, University of Southern Denmark

Calcium sensing and claudin regulation in kidney.

Caroline Bertoye, Centre de recherche des Cordeliers, Hpital europen Georges Pompidou

Claudins in renal calcium physiology.

Gheun-ho Kim, Institute of Biomedical Science, Hanyang University College of Medicine, Seoul, Republic of Korea

The role of renal claudins in calciuria: focusing on metabolic acidosis.

Yu-Juei Hsu, Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center,Taipei,Taiwan, China

The role of renal calcium channels in kidney stone formation.

Milica Bugarski, Institute of Anatomy, University of Zurich

Intravital calcium imaging in the kidney
Subcellular compartments in cardiomyocytes and Heart Failure
Chair: Julia Gorelik , Imperial College London

Co-Chair: Viacheslav Nikolaev , Institute of Experimental Cardiovascular Research Hamburg
Viacheslav Nikolaev, Center for Experimental Medicine, Institute of Experimental Cardiovascular Research Hamburg

cAMP and cGMP compartmentation in cardiomyocytes

Steven Houser, Temple University

Interaction of the Joining Region in Junctophilin-2 with the L-type Ca2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca2+ Dynamics

Julia Gorelik, Imperial College London

Nanoscale regulation of signalling compartemnts in cardiomtocytes during heart fa

William Louch, University of Oslo

Cardiomyocyte substructure reverts to an immature phenotype during heart failure.
Synaptic and network activity to control behavior
Chair: Juan Lerma , Instituto de Neurociencias CSIC-UMH
Pankaj Sah, Queensland Brain Institute

Neural circuits mediating fear learning and extinction

Lu Chen, Department of Psychiatry and Behavioral Sciences, Stanford University, USA

Memory engram reactivation underlies impaired fear memory recall in Fragile X syndrome

Ying-Shing Chan, Li Ka Shing Faculty of Medicine, HKU

Synaptic transmission in rat medial vestibular nucleus and on vestibular-related motor function

Juan Lerma, Instituto de Neurociencias CSIC-UMH

Losing balance: kainate receptors and brain disorders comorbidities
The emerging role for omega-3 fatty acids on muscle functional and metabolic health during ageing and inactivity
Chair: Stuart R Gray , University of Glasgow

Co-Chair: Bettina Mittendorfer , Washington University
Lawrence Spriet, University of Guelph

The effect of omega-3 fatty acids on muscle mitochondrial metabolism

Bettina Mittendorfer, Washington University

The effects of omega-3 fatty acids on muscle protein metabolism

Stuart Gray, University of Glasgow

Omega-3 fatty acids and muscle mass and function in ageing

Chris McGlory, Queens University

The efficacy of omega-3 fatty acids during inactvity
The heterogeneity of inflammation in cardiovascular disease
Chair: Merry Lindsey Lindsey , University of Nebraska Medical Center

Co-Chair: Heddwen Brooks , University of Arizona
Zamaneh Kassiri, University of Alberta, Canada

Cell specific regulation of TIMP4 in modulating inflammation in atherosclerosis and aortic aneurysms

Heddwen Brooks, University of Arizona

Sex specific mechanisms of T cell mediated hypertension: how does estrogen loss contribute to postmenopausal cardiovascular disease

Jennifer Pluznick, Johns Hopkins University

The gut microbiota in cardiovascular disease and hypertension

Justin Van Beusecum, Vanderbilt University Medical Center

Antigen-presenting cells critically modulate inflammation in salt sensitive hypertension

Kristine Deleon-Pennell, Ralph H. Johnson Veterans Affairs Medical Center

Crosstalk between the adaptive and innate immune system in regulating cardiac wound healing
The multiple facets of phosphate - from sensing to calcification
Chair: Carsten Alexander Wagner , University of Zurich, Switzerland

Co-Chair: Jakob Voelkl , Johannes Kepler University Linz, Austria
Carsten Alexander Wagner, University of Zurich. Switzerland

Sensing of phosphate and control of systemic phosphate homeostasis

Orson W Moe, University of Texas Southwestern Medical Center Dallas, USA

Klotho modifies toxicity of phosphate

Jakob Voelkl, Johannes Kepler University, Linz, Austria

Phosphate and vascular inflammation

Qiaoli Li, Thomas Jefferson University, Philadelphia, PA, USA

The role of pyrophosphate in ectopic calcifications
The role of calcium signalling in cytokine and bradykinin storms
Chair: Ole Holger Petersen , Cardiff University

Co-Chair: Anant B Parekh , NIEH, NIH, NC, USA
Ole H Petersen, Cardiff University, UK

Control of bradykinin signalling by cytosolic calcium: lessons from the pancreas

Anant B Parekh, National Institute of Environmental Health Sciences, National Institutes of Health

Targeting store-operated calcium channels to reduce the cytokine storm

Barbara Niemeyer, University of the Saarland

Adapting Calcium Signatures in Health and Disease

Sonal Srikanth, UCLA

SOC Channels and Host Resistance to SARS-Cov-2

Shuang Peng, Jinan University

Tuning of Calcium Signaling and Oxidative Stress in Pancreatic Inflammatory Control
Translating physiology
Chair: Julian Francis Paton , University of Auckland

Co-Chair: Samuel H.H. Chan , Chang Gung Memorial Hospital
Samuel Chan, Chang Gung Memorial Hospital

Baroreflex Functionality in the Eye of Diffusion Tensor Imaging: Clinical and Therapeutic Implications

Richard Horner, University of Toronto

Physiological Rationale and Pharmacological Targets for Sleep Apnoea Pharmacotherapy

Julian Paton, University of Auckland

Using bionics to reverse cardiovascular disease

Emma Hart, University of Bristol

Is high blood pressure self-protection for the brain?

Aaron Phillips, University of Calgary

Mechanism-guided development of an implantable hemotherapy
Trends in enteric neuroscience and mucosal physiology
Chair: Jinxia Zhu , Capital Medical University

Co-Chair: Nick Spencer , Flinders University
Nick Spencer, Flinders University

Optogenetic control of enteric neuronal networks

Xiaodi Tan, Northwestern University

Mechanisms underlying regulation of the gut mucosal homeostasis

Weifang Rong, Shanghai Jiaotong University

Molecular and enteric neuronal substrates mediating estrogenic effects on colonic motility

Lifei Zheng, Capital Medical University

Changes in The Brain-Gut Axis in the development of Gastroparesis in Parkinson's Disease

Yue Yin, Peking University

IAA alleviates DSS-induced colitis in mice
Tubular transportomics and kidney function
Chair: Xiong Zhong Ruan , University College London

Co-Chair: Chuanming Hao , Fudan University
Youfei Guan, Dalian Medical University

Renal tubule transportome and kidney function

Stephen Ben Walsh, University College London

Renal sodium chloride cotransporter and hypertension.

Baoxue Yang, Peking University

Physiological role of urea transporters in kidney

Markus M Rinschen, Aarhus University, Denmark

Viewing kidney tubule function through single nephron mass spectrometry
Uncovering peptides' role in brain function: from synaptic structure to oscillations and behaviour
Chair: Limei Zhang , National Autonomous University of Mexico

Co-Chair: Lee Eiden , NIMH/NIH
Limei Zhang, National Autonomous University of Mexico

Placing neuropeptide signaling within glutamate/GABA contexts reveals its conspicuous role for sensorimotor circuit interaction

Tim Viney, University of Oxford

Contribution of neuropeptide-expressing neuronal cell types to spatial memory processes

Francesco Ferraguti, Medical University of Innsbruck

Cortical vasoactive intestinal polypetide (VIP)-expressing Interneurons and the broadcasting of salience

Lee Eiden, NIMH/NIH

The Evolution of Neuropeptide Modulation: PACAP as a central regulator of endocrine and behavioral responses to stress
Understanding mechanosensitivity
Chair: Alexander Gourine , University College London

Co-Chair: Jessica Filosa , Augusta University
Jessica Filosa, Augusta University

Cerebrovascular mechanosensitivity and regulation of brain blood flow

Weifang Rong, Shanghai Jiaotong University

Molecular and enteric neuronal substrates mediating estrogenic effects on colonic motility

Grant Gordon, University of Calgary

TBD

Alexander Gourine, University College London

Control of cerebral and systemic circulation by an intracranial baroreceptor
Special Symposia - Education
2
Adapting online assessment of student learning to meet the challenges of the pandemic era
Chair: Robert Carroll , Brody School of Medicine at East Carolina University

Co-Chair: Ziqiang Luo , Xiangya Medical School, Central South University
Robert Carroll, Brody School of Medicine at East Carolina University

The unique characteristics and opportunities of assessment of online learning

Dandan Feng, Xiangya Medical School, Central South University

Online flipped Classroom: Students' online learning behavior and academic performance

Louise Robson, University of Sheffield

Authentic online assessments: developing and assessing student problem solving skills

Joanna Howarth, University of Bristol

Creating online quizzes as robust assessments that discourage collusion between students

Xia Yi, Peking University

Capbility-based assessment promotes the reform and development of online teaching in the post-COVID-19 era
Small-group and novel delivery of educational outcomes from a global perspective
Chair: Mohammad Kanpurwala , Karachi Institute of Medical Sciences

Co-Chair: Patricia Halpin , University of New Hampshire at Manchester
Patricia Halpin, Department of Life Sciences, University of New Hampshire at Manchester, Manchester NH USA

Successful Student Engagement in Remote and Asynchronous Courses

Mei-Ling Tsai, National Cheng Kung University

Development of an EPA (Entrustable Professional Activity)-based assessment to consolidate vertical integration of Physiology Lab. Experiences with Physical Examination

Mohammad Kanpurwala, Karachi Institute of Medical Sciences

The use of digital story telling in physiology teaching

Mirza Subhan, University of Plymouth

Physiology taught through inter-professional and team based learning

Yun Wang, Peking University

Innovation on medical education from in-person teaching to a hybrid model with in-person and virtual teaching
Special Symposia - Ethics
1
Animal replacement in physiological studies: progress and validation problems
Chair: Ashima Anand , Vallabhbhai Patel Chest Institute, Delhi University

Co-Chair: Andrea Čalkovská , Department of Physiology, Jessenius Faculty of Medicine, Comenius University
Ashima Anand, Vallabhbhai Patel Chest Institute, Delhi University

The 3 Rs and beyond: ensuring animal welfare and scientific value of research

Octavio Presgrave, Brazilian Center for the Validation of Alternative Methods a Fundao Oswaldo Cruz (BraCVAM/FIOCRUZ), Rio de Janeiro

Alternative methods for animal use in Brazil: state of the art

Yuko Sekino, Endowed Laboratory of Human Cell-Based Drug Discovery, Graduate School of Pharmaceutical Sciences, The University of Tokyo

A successful alternative methods: using human iPS cells-derived cardiomyocytes and neurons

Andrea Čalkovská, Department of Physiology, Jessenius Faculty of Medicine, Comenius University

The way forward: Reaching goals with combined in vitro and in vivo studies/models
Special Symposia - Physiome
1
Integrative computational physiology in Chinese herbal medicine
Chair: Denis Noble , Oxford University

Co-Chair: Yuling Ma , University of Oxford
Peter Hunter, Auckland University

Introducing PHYSIOME modelling and the advantages of the PHYSIOME Journal for analyzing complex physiological networks

Denis Noble, Oxford University

PHYSIOME modelling of skeletal muscle in investigating a Chinese herbal muscle relaxant.

Yuling Ma, University of Oxford

Unravelling the mechanism of a Chinese herbal Medicine using computational prediction

Chae Hun Leem, Department of Physiology, University of Ulsan College of Medicine, Korea

TBD
Special Lunchtime Workshops - Publishing
1
Getting involved with The Journal of Physiology as an author, reviewer or editor
Chair: Kim Barrett , University of California, Davis

Co-Chair: Sally Howells , The Physiological Society
Sponsored by the Physiological Society and Journal of Physiology
Kim Barrett, University of California, Davis

The Journal of Physiology - a hub for the physiology community

Peter Kohl, University of Freiburg

TBD

Bernard Drumm, Dundalk Institute of Technology

Lessons learned as an Editorial Board Fellow for The Journal of Physiology

Sally Howells, The Physiological Society

How The Journal of Physiology adds value to your research paper
Special Lunchtime Workshops - COVID-19
1
The COVID-19 pandemic: origin, development, future
Chair: Ernesto Carafoli , Venetian Institute of Molecular Medicine

Co-Chair: Katsuhiko Mikoshiba , ShanghaiTech University
Zihe Rao, Tsinghua University, Beijing. China

Molecular Biology of the SARS-CoV-2 polymerase

Sarah Rowland-Jones, Sheffield University Medical School

The D614G mutation of the SARS-CoV2 and its role in the pandemic

Rino Rappuoli, Research and Development Centre, GlaxoSmithKline (GSK), 53100 Siena, Italy

Fighting SARS-CoV-2 with immunological wheapons

Luca Zinzula, MPI Biochemistry. Martinsried, Germany

The enigmatic ORF8 protein of SARS-CoV-2

Sara Platto, Jianghan University, Wuhan, China

Biodiversity loss and the role of bats in the origin of the COVID-19 pandemic

About Beijing

Quick Links

Important Dates

1 September 2021

Early Bird Registration opens

1 September 2021

Call for Abstracts

1 September 2021

Virtual Travel Award Application opens

28 February 2022

Deadline for Abstract and Virtual Travel Award

28 February 2022

Deadline for Early Bird Registration

28 February 2022

Scientific Program is ready

15 April 2022

Deadline for Standard Registration

7-11 May 2022

IUPS Congress begins!

Useful Links

Our Contacts

For any registration and general inquiries, please contact:
Ms. Bao Xiaolan, 139 1151 0448 / IUPS2022 PCO
Ms. Chen Qu, 139 0108 5466 / IUPS2022 PCO
iups2022@chinastargroup.com

Symposia

John Speakman, Chinese Academy of Sciences & University of Aberdeen

Clare Stawski, Norwegian University of Technology and Science

Andreas Fahlman, Fundacin oceanografic de la Comunitat valenciana, Spain/ Global Diving Research, Canada

Alina Evans, Inland Norway University of Applied Sciences

Liv Monica Trondrud, Norwegian University of Life Sciences

Schuichi Koizumi, Dept Neuropharmacol, Grad Sch Med, University of Yamanasi, GLIA center, Univ Yamanashi, JAPAN

Baljit Khakh, Physiology and Neurobiology David Geffen School of Medicine, UCLA, USA

Won-Suk Chung, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), South Korea

Misa Arizono, Interdisciplinary Institute for Neuroscience, Universit de Bordeaux, France

Tetsuya Takano, Department of Neurophysiology Keio University School of Medicine, Tokyo, Japan

Patrick Hosford, RIKEN

Anja Teschemacher, University of Bristol

Sheng Wang, Hebei Medical University

Shahriar Sheikhbahaei, National Institute of Neurological Disorders and Stroke (NINDS)

Fang Yuan, Hebei Medical University

Andrea Barbuti, University of Milan

Hua-Qian Yang, Suzhou University

Michael Regnier, University of Washington, Seattle

Ewa Rog-Zielinska,

Heping Cheng, Peking University

Rong Tian, University of Washington

Shey-Shing Sheu, Thomas Jefferson University

Sergio Lavandero, Universidad of Chile

Elizabeth Murphy, National Institutes of Health, United States

Lei Shi, Dalian Medical University

Ingrid Fleming, Goethe University Frankfurt

John Y-J Shyy, University of California, San Diego

Chen Chen, Huazhong University of Science and Technology

Jorge Ruas, Karolinska Institutet

Jennifer Heisz, McMaster University

Harry Gosker, Maastricht University

Phillip Zimmer, Technische Universitt Dortmund

Edwin Lim, Macquarie University Centre for Motor Neuron Disease Research

Ling-Gang WU, National Institute of Health

Zhuan Zhou, Peking University, Beijing

Ira Milošević, Oxford University

Robert Zorec, Univerza v Ljubljani, Medicinska fakulteta

Fabien Brette, INSERM

Ye Chen Izu, UC Davis

Holly Shiels, University of manchester

Chris Tate, Cambridge University

Mark von zastrow, University of California, San Francisco, United States

Crystal Ripplinger, University of California at Davis, United States

Yulong Li, Peking University

Laura Wingler, Duke University

Dora Zelena, Institute of Experimental Medicine, Budapest; Centre for Neuroscience, Szentgothai Research Centre, Institute of Physiology, Medical School, University of Pcs, Pcs, Hungary

Aimin Bao, Department of Mental Health, First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang Province Key Laboratory of Mental Disorder's Management, Hangzhou, China

Andre de Sousa Mecawi, Laboratory of Neuroendocrinology, Department of Biophysics, Escola Paulista de Medicina, Federal University of So Paulo, So Paulo, Brazil.

Carla Daniela Cisternas, Instituto de Investigacin Mdica Mercedes y Martn Ferreyra, INIMEC-CONICET-Universidad Nacional de Crdoba, Crdoba, Argentina.

Vito Salvador Hernandez, Department of Physiology, School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.

Melanie Gareau, School of Veterinary Medicine, University of California, Davis, USA

Xiangsheng Fu, The affiliated Hospital of North Sichuan Medical College, Nanchang, China

Linda Chia-Hui Yu, Graduate Institue of Physiology, National Taiwan University College of Medicine

Colin Reardon, School of Veterinary Medicine, University of California, Davis, USA

Laura Niedernhofer, Institute on the Biology of Aging and Metabolism (iBAM); Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota

Evandro Fei FANG, Department of Clinical Molecular Biology, University of Oslo (UiO) Akershus University Hospital

Heng Ma, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fourth Military Medical University, Xi'an, China

Moshi Song, Institute of Zoology, Chinese Academy of Sciences

Alex Chia Yu Chang, Department of Cardiology and Shanghai Institute of Precision Medicine, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine

Max Gassmann, University of Zurich

Martina Muckenthaler, University of Heidelberg

Ainash Childebayeva, Max Planck Institute for the Science of Human History

David A Esiner, University of Manchester

Karin R Sipido, Department of Cardiovascular Sciences, KU Leuven, The University of Leuven, Belgium

Fatima M Leite, Department of Physiology and Biophysics, Universidade Federal de Minas Gerais (UFMG), MG, Belo Horizonte, Brazil

Luis A Gonano, Cardiovascular Research Center, Faculty of Medicine, National University of La Plata and National Research Council, Argentina

Ivana Y Kuo, Department of Cell and Molecular Physiology, Loyola University Chicago, USA

Ken O'Halloran, Department of Physiology, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland.

Sven Pettersson, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. Singapore Center for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore, Singapore

Vienna Brunt, Integrative Physiology of Ageing Lab, University of Colorado Boulder, USA

Yuuki Obata, UT Southwestern Medical Center

Connie W. Woo, Department of Pharmacology and Pharmacy, University of Hong Kong

Balwant S Tuana, University of Ottawa

Grant Pierce, University of Manitoba

Patrick Burgon, Qatar University

Kate Weeks, Baker Heart and Diabetes Institute

Shi-Qiang Wang, Peking Univ.

Carlos Valverde, Uiversidad Nacional de La Plata

Ana Gomez, INSERM & Universit Paris Sud